Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis.
Identifieur interne : 002202 ( Main/Exploration ); précédent : 002201; suivant : 002203Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis.
Auteurs : Shuquan Rao [République populaire de Chine] ; Yao Yao [République populaire de Chine] ; Chuan Zheng [République populaire de Chine] ; Joanne Ryan [Australie] ; Canquan Mao [République populaire de Chine] ; Fuquan Zhang [République populaire de Chine] ; David Meyre [Canada] ; Qi Xu [République populaire de Chine]Source :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [ 1552-485X ] ; 2016.
Descripteurs français
- KwdFr :
- Canaux calciques de type L (génétique), Canaux calciques de type L (métabolisme), Canaux calciques de type L (physiologie), Facteurs de risque, Femelle, Génotype, Humains, Mâle, Polymorphisme de nucléotide simple (génétique), Population d'origine européenne, Prédisposition génétique à une maladie (génétique), Trouble dépressif majeur (génétique), Trouble dépressif majeur (physiopathologie), Trouble dépressif majeur (psychologie), Variation génétique (génétique), Étude d'association pangénomique.
- MESH :
- génétique : Canaux calciques de type L, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Trouble dépressif majeur, Variation génétique.
- métabolisme : Canaux calciques de type L.
- physiologie : Canaux calciques de type L.
- physiopathologie : Trouble dépressif majeur.
- psychologie : Trouble dépressif majeur.
- Facteurs de risque, Femelle, Génotype, Humains, Mâle, Population d'origine européenne, Étude d'association pangénomique.
English descriptors
- KwdEn :
- Calcium Channels, L-Type (genetics), Calcium Channels, L-Type (metabolism), Calcium Channels, L-Type (physiology), Depressive Disorder, Major (genetics), Depressive Disorder, Major (physiopathology), Depressive Disorder, Major (psychology), European Continental Ancestry Group, Female, Genetic Predisposition to Disease (genetics), Genetic Variation (genetics), Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide (genetics), Risk Factors.
- MESH :
- chemical , genetics : Calcium Channels, L-Type.
- chemical , metabolism : Calcium Channels, L-Type.
- chemical , physiology : Calcium Channels, L-Type.
- genetics : Depressive Disorder, Major, Genetic Predisposition to Disease, Genetic Variation, Polymorphism, Single Nucleotide.
- physiopathology : Depressive Disorder, Major.
- psychology : Depressive Disorder, Major.
- European Continental Ancestry Group, Female, Genome-Wide Association Study, Genotype, Humans, Male, Risk Factors.
Abstract
Major depressive disorder (MDD) is one of the most common psychiatric disorders with a relatively high heritability (35-40%). Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association. Moreover, this locus has never been identified in previous genome-wide association studies (GWAS) for MDD. Here, we conducted a comprehensive meta-analysis of the association between CACNA1C variants and MDD risk by combining all published data. Genetic data from one European GWAS and five individual follow-up studies, which include up to 12,629 patients of MDD and 28,653 controls, that is, the largest sample size on CACNA1C to date, were collected. Rs1006737 showed significant association with MDD in the fixed-effect model (Z = 2.56, P = 0.011, OR = 1.08, 95%CI = 1.04-1.12) and the association remained after reanalyzing the data according to ethnicity. We additionally analyzed other 25 SNPs, genotyped in only one replication study, across the CACNA1C locus, and found that two SNPs, rs4765905 (P = 0.041, OR = 1.05, 95%CI 1.00-1.09) and rs4765937 (P = 0.025, OR = 1.05, 95%CI 1.01-1.09) showed nominal association with MDD, while rs2239073 (P = 0.002, OR = 1.07, 95%CI 1.02-1.11) exhibited significant association with MDD, which survived from multiple corrections. Our study provides support for positive association between CACNA1C and MDD; however, the current data suggest the necessity of replication analyses in a larger-scale sample. © 2016 Wiley Periodicals, Inc.
DOI: 10.1002/ajmg.b.32466
PubMed: 27260792
Affiliations:
- Australie, Canada, République populaire de Chine
- Ontario, Victoria (État)
- Hamilton (Ontario), Melbourne, Pékin
- Université McMaster, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001986
- to stream PubMed, to step Curation: 001962
- to stream PubMed, to step Checkpoint: 001962
- to stream Ncbi, to step Merge: 003641
- to stream Ncbi, to step Curation: 003641
- to stream Ncbi, to step Checkpoint: 003641
- to stream Main, to step Merge: 002201
- to stream Main, to step Curation: 002202
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis.</title><author><name sortKey="Rao, Shuquan" sort="Rao, Shuquan" uniqKey="Rao S" first="Shuquan" last="Rao">Shuquan Rao</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Yao, Yao" sort="Yao, Yao" uniqKey="Yao Y" first="Yao" last="Yao">Yao Yao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Chuan" sort="Zheng, Chuan" uniqKey="Zheng C" first="Chuan" last="Zheng">Chuan Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="4"><nlm:affiliation>Disease Epigenetics Group, Murdoch Children Research Institute and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Disease Epigenetics Group, Murdoch Children Research Institute and Department of Paediatrics, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mao, Canquan" sort="Mao, Canquan" uniqKey="Mao C" first="Canquan" last="Mao">Canquan Mao</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Fuquan" sort="Zhang, Fuquan" uniqKey="Zhang F" first="Fuquan" last="Zhang">Fuquan Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuxi Mental Health Center, Nanjing Medical University, Wuxi</wicri:regionArea><wicri:noRegion>Wuxi</wicri:noRegion></affiliation></author><author><name sortKey="Meyre, David" sort="Meyre, David" uniqKey="Meyre D" first="David" last="Meyre">David Meyre</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><affiliation wicri:level="3"><nlm:affiliation>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27260792</idno><idno type="pmid">27260792</idno><idno type="doi">10.1002/ajmg.b.32466</idno><idno type="wicri:Area/PubMed/Corpus">001986</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001986</idno><idno type="wicri:Area/PubMed/Curation">001962</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001962</idno><idno type="wicri:Area/PubMed/Checkpoint">001962</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001962</idno><idno type="wicri:Area/Ncbi/Merge">003641</idno><idno type="wicri:Area/Ncbi/Curation">003641</idno><idno type="wicri:Area/Ncbi/Checkpoint">003641</idno><idno type="wicri:Area/Main/Merge">002201</idno><idno type="wicri:Area/Main/Curation">002202</idno><idno type="wicri:Area/Main/Exploration">002202</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis.</title><author><name sortKey="Rao, Shuquan" sort="Rao, Shuquan" uniqKey="Rao S" first="Shuquan" last="Rao">Shuquan Rao</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Yao, Yao" sort="Yao, Yao" uniqKey="Yao Y" first="Yao" last="Yao">Yao Yao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Chuan" sort="Zheng, Chuan" uniqKey="Zheng C" first="Chuan" last="Zheng">Chuan Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="4"><nlm:affiliation>Disease Epigenetics Group, Murdoch Children Research Institute and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Disease Epigenetics Group, Murdoch Children Research Institute and Department of Paediatrics, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mao, Canquan" sort="Mao, Canquan" uniqKey="Mao C" first="Canquan" last="Mao">Canquan Mao</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Science and Engineering, Southwest Jiaotong University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Fuquan" sort="Zhang, Fuquan" uniqKey="Zhang F" first="Fuquan" last="Zhang">Fuquan Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuxi Mental Health Center, Nanjing Medical University, Wuxi</wicri:regionArea><wicri:noRegion>Wuxi</wicri:noRegion></affiliation></author><author><name sortKey="Meyre, David" sort="Meyre, David" uniqKey="Meyre D" first="David" last="Meyre">David Meyre</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><affiliation wicri:level="3"><nlm:affiliation>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics</title><idno type="eISSN">1552-485X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium Channels, L-Type (genetics)</term><term>Calcium Channels, L-Type (metabolism)</term><term>Calcium Channels, L-Type (physiology)</term><term>Depressive Disorder, Major (genetics)</term><term>Depressive Disorder, Major (physiopathology)</term><term>Depressive Disorder, Major (psychology)</term><term>European Continental Ancestry Group</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genetic Variation (genetics)</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Canaux calciques de type L (génétique)</term><term>Canaux calciques de type L (métabolisme)</term><term>Canaux calciques de type L (physiologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Population d'origine européenne</term><term>Prédisposition génétique à une maladie (génétique)</term><term>Trouble dépressif majeur (génétique)</term><term>Trouble dépressif majeur (physiopathologie)</term><term>Trouble dépressif majeur (psychologie)</term><term>Variation génétique (génétique)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium Channels, L-Type</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium Channels, L-Type</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Calcium Channels, L-Type</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depressive Disorder, Major</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Canaux calciques de type L</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Trouble dépressif majeur</term><term>Variation génétique</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Canaux calciques de type L</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Canaux calciques de type L</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Trouble dépressif majeur</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Depressive Disorder, Major</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Trouble dépressif majeur</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depressive Disorder, Major</term></keywords><keywords scheme="MESH" xml:lang="en"><term>European Continental Ancestry Group</term><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Population d'origine européenne</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Major depressive disorder (MDD) is one of the most common psychiatric disorders with a relatively high heritability (35-40%). Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association. Moreover, this locus has never been identified in previous genome-wide association studies (GWAS) for MDD. Here, we conducted a comprehensive meta-analysis of the association between CACNA1C variants and MDD risk by combining all published data. Genetic data from one European GWAS and five individual follow-up studies, which include up to 12,629 patients of MDD and 28,653 controls, that is, the largest sample size on CACNA1C to date, were collected. Rs1006737 showed significant association with MDD in the fixed-effect model (Z = 2.56, P = 0.011, OR = 1.08, 95%CI = 1.04-1.12) and the association remained after reanalyzing the data according to ethnicity. We additionally analyzed other 25 SNPs, genotyped in only one replication study, across the CACNA1C locus, and found that two SNPs, rs4765905 (P = 0.041, OR = 1.05, 95%CI 1.00-1.09) and rs4765937 (P = 0.025, OR = 1.05, 95%CI 1.01-1.09) showed nominal association with MDD, while rs2239073 (P = 0.002, OR = 1.07, 95%CI 1.02-1.11) exhibited significant association with MDD, which survived from multiple corrections. Our study provides support for positive association between CACNA1C and MDD; however, the current data suggest the necessity of replication analyses in a larger-scale sample. © 2016 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>République populaire de Chine</li></country><region><li>Ontario</li><li>Victoria (État)</li></region><settlement><li>Hamilton (Ontario)</li><li>Melbourne</li><li>Pékin</li></settlement><orgName><li>Université McMaster</li><li>Université de Melbourne</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Rao, Shuquan" sort="Rao, Shuquan" uniqKey="Rao S" first="Shuquan" last="Rao">Shuquan Rao</name></noRegion><name sortKey="Mao, Canquan" sort="Mao, Canquan" uniqKey="Mao C" first="Canquan" last="Mao">Canquan Mao</name><name sortKey="Xu, Qi" sort="Xu, Qi" uniqKey="Xu Q" first="Qi" last="Xu">Qi Xu</name><name sortKey="Yao, Yao" sort="Yao, Yao" uniqKey="Yao Y" first="Yao" last="Yao">Yao Yao</name><name sortKey="Zhang, Fuquan" sort="Zhang, Fuquan" uniqKey="Zhang F" first="Fuquan" last="Zhang">Fuquan Zhang</name><name sortKey="Zheng, Chuan" sort="Zheng, Chuan" uniqKey="Zheng C" first="Chuan" last="Zheng">Chuan Zheng</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></region></country><country name="Canada"><region name="Ontario"><name sortKey="Meyre, David" sort="Meyre, David" uniqKey="Meyre D" first="David" last="Meyre">David Meyre</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002202 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002202 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27260792
|texte= Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27260792" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |